KCNN4

Across TCGA pan-cancer cohorts, KCNN4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCNN4 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KCNN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNN4 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where KCNN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.179	1.000	.004	17	view →
PDAC	DFS	Quartile	All	0.462	0.792	.037	8	view →
GBM	OS	Tertile	All	0.716	0.374	.023	5	view →
HNSC	DFS	Median	All	0.886	0.417	.049	4	view →
UCEC	OS	Median	III,IV	0.570	1.000	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCNN4–LUAD (DFS)

Open the LUAD breakdown →