KCNN4

Across TCGA patient cohorts, KCNN4 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNN4-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Gab2. Each is linked with KCNN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNN4-to-partner and partner-to-KCNN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KCNN4-low versus KCNN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNN4→partner) and Y-score (partner→KCNN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.258	-1.584	.008	.036	3	1
UCEC	FoxM1 →	+0.208	+1.584	.040	.036	3	1
UCEC	Gab2 →	+0.336	+2.321	.016	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.170	-1.807	.010	.025	3	1
UCEC	Ku80 →	+0.244	+1.598	.008	.022	3	1
UCEC	MEK1 →	+0.303	+2.999	.034	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

EGFR_pY1068 by KCNN4 expression — UCEC

Explore this box plot interactively →