KCNN3

Across TCGA patient cohorts, KCNN3 mutation is significantly associated with the RNA expression of many other genes, with 2,889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNN3-associated genes across cancer lineages are VPS18, PTPRS, and MEST. Each is linked with KCNN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNN3-to-partner and partner-to-KCNN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS18 grouped by KCNN3-low versus KCNN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNN3→partner) and Y-score (partner→KCNN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VPS18 →	+0.693	+3.273	<.001	<.001	3	3
UCEC	PTPRS →	+0.743	+2.094	<.001	<.001	3	3
UCEC	MEST →	-0.608	-1.825	.003	.001	3	3
UCEC	GALNT6 →	-0.724	-1.584	<.001	.005	3	3
UCEC	PFAS →	+0.543	+1.857	<.001	<.001	3	3
SKCM	GPR3 →	+0.568	+2.434	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,889 associations by consensus.

VPS18 by KCNN3 expression — UCEC

Explore this box plot interactively →