KCNN3

Across TCGA cell cohorts, KCNN3 mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNN3-associated genes across cancer lineages are Methotrexate, Doramapimod, and Dactinomycin. Each is linked with KCNN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNN3-to-partner and partner-to-KCNN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methotrexate grouped by KCNN3-low versus KCNN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNN3→partner) and Y-score (partner→KCNN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Methotrexate →	+1.100	+2.807	.004	.046	3	1
LARGE_INTESTINE	Doramapimod →	+0.353	+2.807	.017	.046	3	1
LARGE_INTESTINE	Dactinomycin →	+0.580	+2.710	.005	.027	3	1
LARGE_INTESTINE	50869 →	+0.477	+3.064	.011	.009	3	1
LARGE_INTESTINE	776928 →	+0.584	+2.710	.042	.027	3	1
LARGE_INTESTINE	BPD-00008900 →	+0.428	+2.655	.033	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Methotrexate by KCNN3 expression — LARGE_INTESTINE

Explore this box plot interactively →