KCNN1

Across TCGA patient cohorts, KCNN1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,845 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KCNN1-associated genes across cancer lineages are RPS6KA5, CDC25B, and CPEB3. Each is linked with KCNN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNN1-to-partner and partner-to-KCNN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNN1 versus RPS6KA5 in UCEC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNN1→partner) and Y-score (partner→KCNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS6KA5 →	+0.591	+1.038	.007	.008	3	2
UCEC	CDC25B →	-0.781	-1.454	<.001	.002	3	2
UCEC	CPEB3 →	+0.464	+1.387	<.001	<.001	3	2
UCEC	NCAPG →	-0.954	-1.191	.001	.003	3	2
BRCA	HPX →	+1.069	+1.187	.001	<.001	3	2
BRCA	TRIM3 →	+0.652	+1.074	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,845 associations by consensus.

KCNN1 vs RPS6KA5 — UCEC

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