KCNN1

Across TCGA cell cohorts, KCNN1 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNN1-associated genes across cancer lineages are FOXS1, GNPNAT1, and CNIH1. Each is linked with KCNN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNN1-to-partner and partner-to-KCNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXS1 grouped by KCNN1-low versus KCNN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNN1→partner) and Y-score (partner→KCNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FOXS1 →	+0.046	+3.551	.008	.008	3	2
LARGE_INTESTINE	GNPNAT1 →	+0.621	+2.714	<.001	.002	3	1
LARGE_INTESTINE	CNIH1 →	+0.537	+2.714	<.001	.002	3	1
LARGE_INTESTINE	RAB5IF →	-0.623	-3.459	.001	.001	3	1
LARGE_INTESTINE	MYL9 →	-1.587	-2.541	.005	.005	3	1
LARGE_INTESTINE	CHN2 →	-0.895	-3.657	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

FOXS1 by KCNN1 expression — BLOOD_Leukemia

Explore this box plot interactively →