KCNMB4

Across TCGA patient cohorts, KCNMB4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNMB4-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and ACVRL1. Each is linked with KCNMB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNMB4-to-partner and partner-to-KCNMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by KCNMB4-low versus KCNMB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNMB4→partner) and Y-score (partner→KCNMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.120	-2.312	.046	.034	3	1
UCEC	GAPDH →	+0.679	+3.000	.008	.036	2	2
UCEC	ACVRL1 →	-0.151	-2.302	.021	.034	3	1
UCEC	JNK2 →	+0.328	+2.459	<.001	.020	3	1
UCEC	Ku80 →	+0.280	+2.820	.014	.035	3	1
UCEC	N-Ras →	-0.150	-2.980	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FOXO3a_pS318_S321 by KCNMB4 expression — UCEC

Explore this box plot interactively →