KCNMB4

Across TCGA cell cohorts, KCNMB4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNMB4-associated genes across cancer lineages are SYCN, USP17L3, and ACOD1. Each is linked with KCNMB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNMB4-to-partner and partner-to-KCNMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYCN grouped by KCNMB4-low versus KCNMB4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNMB4→partner) and Y-score (partner→KCNMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYCN →	+0.047	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L3 →	+0.012	+4.922	.009	.009	3	1
LUNG_NSCLC_LUAD	ACOD1 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR7G1 →	+0.023	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SYCN by KCNMB4 expression — BLOOD_Leukemia

Explore this box plot interactively →