KCNMB3

Across TCGA patient cohorts, KCNMB3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNMB3-associated genes across cancer lineages are PKC-delta_pS664, JNK_pT183_Y185, and PCNA. Each is linked with KCNMB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNMB3-to-partner and partner-to-KCNMB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by KCNMB3-low versus KCNMB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNMB3→partner) and Y-score (partner→KCNMB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.128	-3.321	.042	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.214	-3.000	.015	.036	3	1
UCEC	PCNA →	+0.284	+2.999	.012	.035	3	1
UCEC	Annexin-1 →	+0.596	+2.827	.030	.035	3	1
UCEC	ATM →	-0.897	-3.000	<.001	.036	2	2
UCEC	Caspase-7-cleavedD198 →	+1.114	+3.019	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PKC-delta_pS664 by KCNMB3 expression — UCEC

Explore this box plot interactively →