KCNMB3

Across TCGA cell cohorts, KCNMB3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KCNMB3-associated genes across cancer lineages are SIGLEC8, GPR101, and OR4D5. Each is linked with KCNMB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNMB3-to-partner and partner-to-KCNMB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by KCNMB3-low versus KCNMB3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNMB3→partner) and Y-score (partner→KCNMB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	GPR101 →	+0.015	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.019	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SIGLEC8 by KCNMB3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →