KCNMB1

Across TCGA pan-cancer cohorts, KCNMB1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KCNMB1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KCNMB1 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNMB1 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and KIRC are the cancer types where KCNMB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNMB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−4.767	<.001	11	view →
KICH	All	IV	−1.207	<.001	11	view →
KIRC	Female	All	+1.012	<.001	11	view →
COAD	Male	II,III,IV	−2.290	<.001	8	view →
LIHC	Female	All	+0.412	<.001	7	view →
UCEC	All	All	−3.808	<.001	6	view →
STAD	Female	All	−2.854	<.001	6	view →
BRCA	Female	II,III,IV	−2.380	<.001	6	view →
LUSC	All	All	−0.521	<.001	6	view →
READ	All	All	−2.950	<.001	4	view →
CHOL	All	All	+0.993	<.001	3	view →
PRAD	All	All	−1.380	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KCNMB1–BLCA

Open the BLCA breakdown →