KCNMA1

Across TCGA pan-cancer cohorts, KCNMA1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated KCNMA1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher KCNMA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNMA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

KICH, CESC, and LUAD are the cancer types where KCNMA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.161	0.881	<.001	24	view →
CESC	DFS	Median	III,IV	0.154	0.738	<.001	18	view →
LUAD	OS	Median	III,IV	0.083	0.680	<.001	18	view →
UCEC	DFS	Median	All	0.829	0.617	.006	16	view →
ESCA	OS	Median	II,III,IV	0.136	0.687	.002	9	view →
LIHC	DFS	Median	All	0.158	0.544	.043	6	view →
STAD	DFS	Median	II,III,IV	0.696	0.353	.029	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	III,IV	0.715	0.239	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

KCNMA1–KICH (OS)

Open the KICH breakdown →