KCNMA1

Across TCGA pan-cancer cohorts, KCNMA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KCNMA1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KCNMA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KCNMA1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where KCNMA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.787	0.989	.004	20	view →
LUAD	DFS	Tertile	III,IV	0.640	1.000	.018	16	view →
CCRCC	DFS	Quartile	All	1.000	0.445	.006	9	view →
UCEC	OS	Median	All	0.981	0.918	.046	2	view →
HNSC	DFS	Quartile	II,III,IV	0.701	0.934	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KCNMA1–LSCC (OS)

Open the LSCC breakdown →