KCNMA1

Across TCGA cell cohorts, KCNMA1 mutation is significantly associated with the RNA expression of many other genes, with 788 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNMA1-associated genes across cancer lineages are GFRA4, ZIC5, and GNPNAT1. Each is linked with KCNMA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNMA1-to-partner and partner-to-KCNMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by KCNMA1-low versus KCNMA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNMA1→partner) and Y-score (partner→KCNMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GFRA4 →	+0.277	+4.087	<.001	.002	3	2
BLOOD_Leukemia	ZIC5 →	+0.415	+2.697	.005	.008	3	2
LARGE_INTESTINE	GNPNAT1 →	+0.524	+2.829	.002	<.001	3	2
LARGE_INTESTINE	BCAT2 →	+0.563	+2.743	.001	.001	3	2
LARGE_INTESTINE	HOXA3 →	-1.303	-3.169	<.001	.006	3	2
LARGE_INTESTINE	MAPK8 →	+0.559	+3.169	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 788 associations by consensus.

GFRA4 by KCNMA1 expression — LUNG_SCLC

Explore this box plot interactively →