KCNK9

Across TCGA patient cohorts, KCNK9 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK9-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and c-Met. Each is linked with KCNK9 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNK9-to-partner and partner-to-KCNK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KCNK9-low versus KCNK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK9→partner) and Y-score (partner→KCNK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.180	+2.000	.018	.003	3	3
UCEC	Caspase-7-cleavedD198 →	+0.624	+1.341	.002	.043	3	3
SKCM	c-Met →	+0.142	+1.602	.025	.042	3	2
UCEC	JNK_pT183_Y185 →	-0.136	-1.765	.022	.013	3	2
UCEC	Src_pY527 →	-0.328	-2.212	.031	.010	3	2
UCEC	4E-BP1 →	+0.335	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PCNA by KCNK9 expression — UCEC

Explore this box plot interactively →