KCNK6

Across TCGA patient cohorts, KCNK6 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK6-associated genes across cancer lineages are GSK-3a-b_pS21_S9, JNK2, and MEK1. Each is linked with KCNK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK6-to-partner and partner-to-KCNK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by KCNK6-low versus KCNK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK6→partner) and Y-score (partner→KCNK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.460	+3.321	.039	.010	3	1
UCEC	JNK2 →	+0.258	+3.009	.013	.019	3	1
UCEC	MEK1 →	+0.620	+3.321	.001	.010	3	1
UCEC	Notch1 →	+0.235	+2.179	.001	.034	3	1
UCEC	PDCD4 →	-0.524	-3.321	.033	.010	3	1
UCEC	C-Raf →	+0.288	+2.999	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GSK-3a-b_pS21_S9 by KCNK6 expression — UCEC

Explore this box plot interactively →