KCNK6

Across TCGA cell cohorts, KCNK6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,941 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNK6-associated GO terms across cancer lineages are Regulation of protein localization to cell periphery, Actin filament organization, and Surfactant homeostasis. Each is linked with KCNK6 in more than 11 cancer types. Because this analysis shows association rather than direction, both KCNK6-to-partner and partner-to-KCNK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to cell periphery grouped by KCNK6-low versus KCNK6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK6→partner) and Y-score (partner→KCNK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to cell periphery →	+0.068	+1.222	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Actin filament organization →	+0.065	+1.024	.005	.004	3	12
LUNG_NSCLC_LUSC	Surfactant homeostasis →	+0.235	+0.957	<.001	.008	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of tumor necrosis factor superfamily cytokine production →	+0.099	+1.310	<.001	<.001	3	11
BONE	Negative regulation of intrinsic apoptotic signaling pathway →	+0.100	+1.398	.002	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of tumor necrosis factor production →	+0.105	+1.410	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,941 associations by consensus.

Regulation of protein localization to cell periphery by KCNK6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →