KCNK5

Across TCGA pan-cancer cohorts, KCNK5 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KCNK5 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KCNK5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and LUAD are the cancer types where KCNK5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.467	0.856	<.001	28	view →
UCEC	DFS	Median	All	1.000	0.828	.010	20	view →
LUAD	OS	Median	All	0.313	0.812	.015	9	view →
KIRP	OS	Median	All	0.105	0.688	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KCNK5–COAD (OS)

Open the COAD breakdown →