KCNK5

Across TCGA patient cohorts, KCNK5 mutation is significantly associated with the RNA expression of many other genes, with 3,523 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK5-associated genes across cancer lineages are RPS29P32, RNA5SP412, and PIGW. Each is linked with KCNK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK5-to-partner and partner-to-KCNK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P32 grouped by KCNK5-low versus KCNK5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK5→partner) and Y-score (partner→KCNK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+0.309	+1.936	.001	.008	3	2
UCEC	RNA5SP412 →	+0.445	+1.879	.001	.003	3	2
UCEC	PIGW →	+0.623	+3.534	<.001	<.001	3	2
UCEC	GPIHBP1 →	-0.412	-3.636	.002	.001	3	2
PRAD	RNU6-419P →	+1.327	+5.352	<.001	.006	3	2
PRAD	COX6B1P6 →	+0.189	+5.420	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,523 associations by consensus.

RPS29P32 by KCNK5 expression — UCEC

Explore this box plot interactively →