KCNK5

Across TCGA patient cohorts, KCNK5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK5-associated genes across cancer lineages are HER2_pY1248, Caspase-8, and MSH2. Each is linked with KCNK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK5-to-partner and partner-to-KCNK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by KCNK5-low versus KCNK5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK5→partner) and Y-score (partner→KCNK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2_pY1248 →	-0.158	-3.321	.015	.009	3	2
UCEC	Caspase-8 →	-0.192	-2.195	.041	.009	3	2
UCEC	MSH2 →	-0.325	-2.558	<.001	.010	3	2
UCEC	MSH6 →	-0.470	-2.459	<.001	.018	3	2
UCEC	CD49b →	-0.218	-3.156	.041	.018	3	2
SKCM	HER2 →	-0.330	-3.309	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

HER2_pY1248 by KCNK5 expression — SKCM

Explore this box plot interactively →