KCNK3

Across TCGA patient cohorts, KCNK3 mutation is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK3-associated genes across cancer lineages are RNU6-673P, SNORA79, and ZBTB8OS. Each is linked with KCNK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK3-to-partner and partner-to-KCNK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-673P grouped by KCNK3-low versus KCNK3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK3→partner) and Y-score (partner→KCNK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-673P →	+0.375	+6.676	<.001	<.001	3	2
LIHC	SNORA79 →	+0.389	+5.355	<.001	.005	3	2
UCEC	ZBTB8OS →	+0.371	+3.823	.001	<.001	3	2
UCEC	UFD1 →	+0.350	+1.960	.003	.009	3	2
LUAD	RNA5SP359 →	+0.470	+4.990	<.001	.009	3	2
UCEC	RNA5SP455 →	+0.219	+4.055	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

RNU6-673P by KCNK3 expression — LIHC

Explore this box plot interactively →