KCNK2

Across TCGA patient cohorts, KCNK2 mutation is significantly associated with the RNA expression of many other genes, with 3,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK2-associated genes across cancer lineages are CARS1, MIR548B, and CCL4. Each is linked with KCNK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNK2-to-partner and partner-to-KCNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARS1 grouped by KCNK2-low versus KCNK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK2→partner) and Y-score (partner→KCNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CARS1 →	+0.413	+2.010	<.001	<.001	3	4
BRCA	MIR548B →	+0.311	+4.341	<.001	.009	3	3
UCEC	CCL4 →	+0.781	+2.294	<.001	<.001	3	3
UCEC	TONSL →	+0.537	+2.264	<.001	.001	3	3
UCEC	SLC4A2 →	+0.430	+1.562	.003	.002	3	3
UCEC	STIP1 →	+0.460	+2.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,867 associations by consensus.

CARS1 by KCNK2 expression — UCEC

Explore this box plot interactively →