KCNK2

Across TCGA patient cohorts, KCNK2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK2-associated genes across cancer lineages are ATM, 4E-BP1_pT37_T46, and Cyclin-B1. Each is linked with KCNK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK2-to-partner and partner-to-KCNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KCNK2-low versus KCNK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK2→partner) and Y-score (partner→KCNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.365	-2.571	.013	.010	3	2
UCEC	4E-BP1_pT37_T46 →	-0.271	-1.986	.026	.029	3	2
UCEC	Cyclin-B1 →	+0.452	+1.807	.013	.025	3	2
UCEC	Di-Ras3 →	-0.117	-2.571	.014	.010	3	2
COAD	Caspase-7-cleavedD198 →	+1.208	+2.824	.003	.034	3	2
COAD	Chk1_pS345 →	+0.192	+2.824	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by KCNK2 expression — UCEC

Explore this box plot interactively →