Across TCGA patient cohorts, KCNK18 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KCNK18-associated genes across cancer lineages are MIG-6, C-Raf, and ATM. Each is linked with KCNK18 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNK18-to-partner and partner-to-KCNK18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK18→partner) and Y-score (partner→KCNK18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.110	+2.866	.043	.033	3	3
COAD	C-Raf →	+0.204	+2.815	.011	.036	3	3
UCEC	ATM →	-0.542	-3.321	.004	.010	3	2
SKCM	C-Raf_pS338 →	+0.138	+2.584	.017	.011	3	2
UCEC	Notch1 →	+0.145	+2.179	.015	.034	3	1
UCEC	Annexin-1 →	+0.620	+3.189	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

KCNK18 survival (RNA) · tumor vs normal (RNA) · all KCNK18 data types