Across TCGA cell cohorts, KCNK18 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNK18-associated genes across cancer lineages are IL36B, PROP1, and IL20. Each is linked with KCNK18 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK18-to-partner and partner-to-KCNK18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK18→partner) and Y-score (partner→KCNK18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL36B →	+0.035	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PROP1 →	+0.012	+4.867	.001	.009	3	1
LARGE_INTESTINE	IL20 →	+0.225	+3.662	<.001	.009	2	1
LARGE_INTESTINE	GAS2L2 →	+0.094	+3.807	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

KCNK18 survival (RNA) · tumor vs normal (RNA) · all KCNK18 data types