KCNK17

Across TCGA patient cohorts, KCNK17 mutation is significantly associated with the RNA expression of many other genes, with 2,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK17-associated genes across cancer lineages are RNU6-2, KLHL23, and RFKP1. Each is linked with KCNK17 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK17-to-partner and partner-to-KCNK17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-2 grouped by KCNK17-low versus KCNK17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK17→partner) and Y-score (partner→KCNK17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-2 →	+0.769	+2.930	.001	.002	3	2
UCEC	KLHL23 →	+1.010	+3.757	<.001	<.001	3	2
UCEC	RFKP1 →	+0.102	+2.541	<.001	.007	3	2
UCEC	IFI30 →	+0.368	+3.475	.009	.002	3	2
UCEC	HNRNPA1P56 →	+0.143	+2.269	<.001	.006	3	2
UCEC	KRT8P46 →	+0.344	+2.641	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,598 associations by consensus.

RNU6-2 by KCNK17 expression — UCEC

Explore this box plot interactively →