KCNK17

Across TCGA patient cohorts, KCNK17 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK17-associated genes across cancer lineages are FASN, ACC_pS79, and GAPDH. Each is linked with KCNK17 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK17-to-partner and partner-to-KCNK17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by KCNK17-low versus KCNK17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK17→partner) and Y-score (partner→KCNK17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.566	+2.000	.001	.032	3	1
UCEC	ACC_pS79 →	+0.384	+2.700	.014	.006	3	1
UCEC	GAPDH →	+0.477	+2.999	.049	.035	3	1
UCEC	GATA6 →	-0.173	-2.693	.013	.006	3	1
UCEC	ACC1 →	+0.460	+2.820	.005	.035	3	1
UCEC	Heregulin →	-0.152	-2.308	.006	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FASN by KCNK17 expression — UCEC

Explore this box plot interactively →