KCNK17

Across TCGA cell cohorts, KCNK17 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KCNK17-associated genes across cancer lineages are GPR139, HIGD1C, and CRX. Each is linked with KCNK17 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK17-to-partner and partner-to-KCNK17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR139 grouped by KCNK17-low versus KCNK17-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK17→partner) and Y-score (partner→KCNK17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPR139 →	+0.022	+5.369	<.001	.004	3	1
BLOOD_Leukemia	HIGD1C →	+0.091	+5.201	<.001	.006	3	1
SKIN	CRX →	+0.007	+4.930	<.001	.001	3	1
SKIN	KRTAP2-1 →	+0.193	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GPR139 by KCNK17 expression — SOFT_TISSUE

Explore this box plot interactively →