KCNK13

Across TCGA patient cohorts, KCNK13 mutation is significantly associated with the RNA expression of many other genes, with 2,107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK13-associated genes across cancer lineages are RN7SKP186, CHEK1, and BLM. Each is linked with KCNK13 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNK13-to-partner and partner-to-KCNK13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP186 grouped by KCNK13-low versus KCNK13-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK13→partner) and Y-score (partner→KCNK13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP186 →	+0.043	+2.312	<.001	.009	3	4
LUAD	CHEK1 →	+0.885	+3.223	.002	.009	3	3
LUAD	BLM →	+0.878	+3.366	<.001	.004	3	3
LUAD	RNA5SP158 →	+0.272	+3.216	<.001	.006	3	3
COAD	RN7SKP265 →	+0.286	+4.409	<.001	.004	3	3
UCEC	RNU6-1213P →	+0.125	+3.069	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,107 associations by consensus.

RN7SKP186 by KCNK13 expression — SKCM

Explore this box plot interactively →