KCNK10

Across TCGA patient cohorts, KCNK10 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK10-associated genes across cancer lineages are JNK_pT183_Y185, 4E-BP1, and Cyclin-B1. Each is linked with KCNK10 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNK10-to-partner and partner-to-KCNK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by KCNK10-low versus KCNK10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK10→partner) and Y-score (partner→KCNK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.156	-1.765	.002	.011	3	3
UCEC	4E-BP1 →	+0.301	+1.893	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.593	+1.925	<.001	.004	3	3
LUSC	GAPDH →	+0.852	+3.000	.001	.033	3	2
LUSC	Raptor →	+0.214	+2.335	.012	.018	3	2
LUSC	cIAP →	+0.132	+1.594	.006	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

JNK_pT183_Y185 by KCNK10 expression — UCEC

Explore this box plot interactively →