KCNJ8

Across TCGA patient cohorts, KCNJ8 mutation is significantly associated with the RNA expression of many other genes, with 2,502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ8-associated genes across cancer lineages are PRC1, MFN2, and CHAF1A. Each is linked with KCNJ8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ8-to-partner and partner-to-KCNJ8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRC1 grouped by KCNJ8-low versus KCNJ8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ8→partner) and Y-score (partner→KCNJ8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRC1 →	+0.578	+2.510	.007	.001	3	3
UCEC	MFN2 →	+0.438	+2.743	.002	.002	3	3
UCEC	CHAF1A →	+0.644	+2.828	<.001	<.001	3	3
COAD	HIRIP3 →	+0.563	+3.598	<.001	.001	3	3
UCEC	RRM1 →	+0.601	+3.721	.005	<.001	3	3
COAD	REEP4 →	+0.549	+3.598	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,502 associations by consensus.

PRC1 by KCNJ8 expression — UCEC

Explore this box plot interactively →