KCNJ8

Across TCGA patient cohorts, KCNJ8 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ8-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with KCNJ8 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNJ8-to-partner and partner-to-KCNJ8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by KCNJ8-low versus KCNJ8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ8→partner) and Y-score (partner→KCNJ8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JNK_pT183_Y185 →	-0.128	-1.906	.018	.016	3	4
UCEC	Caspase-7-cleavedD198 →	+0.860	+1.720	<.001	.025	3	3
UCEC	EGFR_pY1068 →	-0.286	-2.584	.002	.001	3	2
SKCM	p62 Lck ligand →	+0.380	+1.906	.013	.016	3	2
UCEC	PARP_cleaved →	-0.233	-2.906	.049	.001	3	2
UCEC	Shc_pY317 →	-0.164	-2.584	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

JNK_pT183_Y185 by KCNJ8 expression — SKCM

Explore this box plot interactively →