KCNJ8

Across TCGA cell cohorts, KCNJ8 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,671 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNJ8-associated GO terms across cancer lineages are Ionotropic glutamate receptor signaling pathway, Ligand-gated ion channel signaling pathway, and Biological process involved in interaction with symbiont. Each is linked with KCNJ8 in more than 6 cancer types. Because this analysis shows association rather than direction, both KCNJ8-to-partner and partner-to-KCNJ8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ionotropic glutamate receptor signaling pathway grouped by KCNJ8-low versus KCNJ8-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ8→partner) and Y-score (partner→KCNJ8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Ionotropic glutamate receptor signaling pathway →	-0.133	-1.785	<.001	<.001	3	7
LARGE_INTESTINE	Ligand-gated ion channel signaling pathway →	-0.131	-1.617	.001	.002	3	6
SOFT_TISSUE	Biological process involved in interaction with symbiont →	+0.212	+0.850	<.001	<.001	3	6
SOFT_TISSUE	Lactate metabolic process →	+0.101	+0.586	<.001	.008	2	7
UPPER_AERODIGESTIVE_TRACT	Regulation of translational elongation →	+0.077	+0.183	<.001	.002	3	6
SKIN	Telomere tethering at nuclear periphery →	+0.055	+0.513	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,671 associations by consensus.

Ionotropic glutamate receptor signaling pathway by KCNJ8 expression — LARGE_INTESTINE

Explore this box plot interactively →