KCNJ8

Across TCGA cell cohorts, KCNJ8 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNJ8-associated genes across cancer lineages are AZD5153, JAK1_8709, and LMB_AB3. Each is linked with KCNJ8 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ8-to-partner and partner-to-KCNJ8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD5153 grouped by KCNJ8-low versus KCNJ8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ8→partner) and Y-score (partner→KCNJ8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD5153 →	+0.674	+2.649	.006	.046	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.420	+2.649	.034	.046	3	1
LARGE_INTESTINE	LMB_AB3 →	+0.421	+2.649	.017	.046	3	1
LARGE_INTESTINE	Tenovin-6 →	+0.432	+2.786	.035	.037	3	1
LARGE_INTESTINE	Ara-G →	+0.174	+2.722	.039	.040	3	1
LARGE_INTESTINE	IAP_5620 →	+0.369	+2.649	.045	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AZD5153 by KCNJ8 expression — LARGE_INTESTINE

Explore this box plot interactively →