KCNJ6

Across TCGA patient cohorts, KCNJ6 mutation is significantly associated with the RNA expression of many other genes, with 944 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KCNJ6-associated genes across cancer lineages are MTCO2P34, RPS17P15, and MIR548AO. Each is linked with KCNJ6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ6-to-partner and partner-to-KCNJ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO2P34 grouped by KCNJ6-low versus KCNJ6-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ6→partner) and Y-score (partner→KCNJ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MTCO2P34 →	+0.214	+4.341	<.001	.007	3	2
READ	RPS17P15 →	+0.347	+3.827	<.001	.006	3	2
CESC	MIR548AO →	+0.424	+4.595	.005	.001	3	2
BLCA	OR51S1 →	+0.043	+5.722	<.001	.001	3	2
CESC	RNU6-177P →	+0.359	+5.124	<.001	<.001	3	2
CESC	CYCSP12 →	+0.147	+5.554	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 944 associations by consensus.

MTCO2P34 by KCNJ6 expression — READ

Explore this box plot interactively →