KCNJ6

Across TCGA patient cohorts, KCNJ6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ6-associated genes across cancer lineages are Caspase-7-cleavedD198, CD49b, and JNK_pT183_Y185. Each is linked with KCNJ6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ6-to-partner and partner-to-KCNJ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KCNJ6-low versus KCNJ6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ6→partner) and Y-score (partner→KCNJ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.754	+3.019	.015	.019	3	2
SKCM	CD49b →	+0.216	+1.782	.013	.008	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-2.999	.033	.035	3	1
UCEC	Ku80 →	+0.332	+2.183	.007	.035	3	1
UCEC	MEK1 →	+0.475	+3.321	.013	.010	3	1
UCEC	VHL →	-1.238	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by KCNJ6 expression — UCEC

Explore this box plot interactively →