KCNJ6

Across TCGA cell cohorts, KCNJ6 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNJ6-associated genes across cancer lineages are RTP3, UCMA, and APCS. Each is linked with KCNJ6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ6-to-partner and partner-to-KCNJ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP3 grouped by KCNJ6-low versus KCNJ6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ6→partner) and Y-score (partner→KCNJ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RTP3 →	+0.201	+3.295	.002	.009	3	1
LARGE_INTESTINE	UCMA →	+0.015	+3.217	<.001	.006	3	1
SKIN	APCS →	+0.057	+3.345	<.001	.007	3	1
SKIN	CFC1B →	+0.035	+4.022	<.001	.006	3	1
SKIN	DNAI2 →	+0.144	+4.518	<.001	<.001	3	1
SKIN	OR13C3 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RTP3 by KCNJ6 expression — LARGE_INTESTINE

Explore this box plot interactively →