KCNJ6

Across TCGA cell cohorts, KCNJ6 mutation is significantly associated with the mutation status of many other genes, with 1,490 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNJ6-associated genes across cancer lineages are ZBTB14, FCRL3, and ZNF668. Each is linked with KCNJ6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ6-to-partner and partner-to-KCNJ6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB14 grouped by KCNJ6-low versus KCNJ6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ6→partner) and Y-score (partner→KCNJ6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZBTB14 →	+3.823	+4.430	.001	.001	1	3
BLOOD_Leukemia	FCRL3 →	+3.823	+4.430	.001	.001	1	3
BLOOD_Leukemia	ZNF668 →	+3.560	+5.209	<.001	<.001	1	3
BLOOD_Leukemia	ARHGAP1 →	+6.145	+5.479	<.001	<.001	1	3
BLOOD_Leukemia	TSKU →	+5.560	+4.736	.003	.003	1	3
SKIN	DGKG →	+3.117	+3.117	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,490 associations by consensus.

ZBTB14 by KCNJ6 expression — BLOOD_Leukemia

Explore this box plot interactively →