KCNJ5

Across TCGA pan-cancer cohorts, KCNJ5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KCNJ5 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher KCNJ5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNJ5 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KICH, SKCM, and SARC are the cancer types where KCNJ5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	II,III,IV	0.834	0.540	.016	11	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KCNJ5–KICH (DFS)

Open the KICH breakdown →