KCNJ5

Across TCGA patient cohorts, KCNJ5 mutation is significantly associated with the RNA expression of many other genes, with 1,340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ5-associated genes across cancer lineages are PGRMC2, PRORP, and TAF9. Each is linked with KCNJ5 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNJ5-to-partner and partner-to-KCNJ5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGRMC2 grouped by KCNJ5-low versus KCNJ5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ5→partner) and Y-score (partner→KCNJ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PGRMC2 →	+0.645	+3.328	<.001	<.001	3	3
UCEC	PRORP →	+0.295	+1.818	.001	.002	3	3
UCEC	TAF9 →	+0.516	+3.021	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.439	+1.967	<.001	.001	3	2
SKCM	CICP15 →	+0.006	+2.526	<.001	.002	3	2
LUAD	TTTY20 →	+0.414	+4.333	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,340 associations by consensus.

PGRMC2 by KCNJ5 expression — SKCM

Explore this box plot interactively →