KCNJ5

Across TCGA patient cohorts, KCNJ5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ5-associated genes across cancer lineages are eIF4E, JNK2, and MEK1. Each is linked with KCNJ5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ5-to-partner and partner-to-KCNJ5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KCNJ5-low versus KCNJ5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ5→partner) and Y-score (partner→KCNJ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.235	+2.598	.002	.005	3	1
UCEC	JNK2 →	+0.156	+1.901	.032	.028	3	1
UCEC	MEK1 →	+0.354	+2.321	.008	.005	3	1
UCEC	MSH2 →	-0.281	-2.433	<.001	.018	3	1
UCEC	MSH6 →	-0.424	-2.459	<.001	.018	3	1
UCEC	TIGAR →	+0.138	+1.529	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by KCNJ5 expression — UCEC

Explore this box plot interactively →