KCNJ5

Across TCGA cell cohorts, KCNJ5 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KCNJ5-associated genes across cancer lineages are AVP, MRGPRX2, and OCM2. Each is linked with KCNJ5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ5-to-partner and partner-to-KCNJ5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by KCNJ5-low versus KCNJ5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ5→partner) and Y-score (partner→KCNJ5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AVP →	+0.052	+5.149	<.001	<.001	3	2
LUNG_NSCLC_LUAD	MRGPRX2 →	+0.026	+4.093	.008	.004	3	2
LUNG_NSCLC_LUAD	OCM2 →	+0.041	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	PSMA8 →	+0.201	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1M1 →	+0.024	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	IQCF5 →	+0.040	+4.189	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AVP by KCNJ5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →