KCNJ3

Across TCGA pan-cancer cohorts, KCNJ3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KCNJ3 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher KCNJ3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNJ3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

READ, UCEC, and LIHC are the cancer types where KCNJ3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	III,IV	0.059	0.761	<.001	12	view →
UCEC	DFS	Median	III,IV	0.874	0.526	.038	4	view →
LIHC	DFS	Median	II,III,IV	0.041	0.418	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KCNJ3–READ (DFS)

Open the READ breakdown →