KCNJ2

Across TCGA cell cohorts, KCNJ2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNJ2-associated genes across cancer lineages are DEFB108B, GUCA2A, and TBC1D21. Each is linked with KCNJ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ2-to-partner and partner-to-KCNJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by KCNJ2-low versus KCNJ2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ2→partner) and Y-score (partner→KCNJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFB108B →	+0.129	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.025	+4.353	<.001	.001	3	1
LARGE_INTESTINE	OR4F4 →	+0.023	+3.688	<.001	.002	3	1
LARGE_INTESTINE	KRT73 →	+0.076	+4.518	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DEFB108B by KCNJ2 expression — BLOOD_Leukemia

Explore this box plot interactively →