KCNJ15

Across TCGA patient cohorts, KCNJ15 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ15-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, MEK1, and PCNA. Each is linked with KCNJ15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ15-to-partner and partner-to-KCNJ15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by KCNJ15-low versus KCNJ15-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ15→partner) and Y-score (partner→KCNJ15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.679	+2.222	.003	.010	3	2
UCEC	MEK1 →	+0.345	+2.700	.019	.006	3	2
UCEC	PCNA →	+0.192	+2.999	.027	.035	3	2
UCEC	TFRC →	+0.574	+1.906	.007	.016	3	2
UCEC	Caspase-8 →	-0.338	-3.087	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.175	+2.415	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Acetyl-a-Tubulin-Lys40 by KCNJ15 expression — SKCM

Explore this box plot interactively →