KCNJ13

Across TCGA patient cohorts, KCNJ13 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ13-associated genes across cancer lineages are STAT3_pY705, 4E-BP1, and Notch1. Each is linked with KCNJ13 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ13-to-partner and partner-to-KCNJ13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by KCNJ13-low versus KCNJ13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ13→partner) and Y-score (partner→KCNJ13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.398	-2.000	<.001	.032	3	2
UCEC	4E-BP1 →	+0.348	+2.199	.004	.033	3	2
UCEC	Notch1 →	+0.203	+3.807	.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.346	+2.331	.018	.019	3	1
UCEC	Rad50 →	-0.227	-2.000	.038	.032	3	1
UCEC	Annexin-1 →	+0.652	+3.189	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

STAT3_pY705 by KCNJ13 expression — UCEC

Explore this box plot interactively →