KCNJ1

Across TCGA patient cohorts, KCNJ1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNJ1-associated genes across cancer lineages are PEA-15_pS116, ATM, and Caspase-7-cleavedD198. Each is linked with KCNJ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNJ1-to-partner and partner-to-KCNJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by KCNJ1-low versus KCNJ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ1→partner) and Y-score (partner→KCNJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.369	+2.321	.007	.033	3	2
UCEC	ATM →	-0.656	-3.446	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.887	+2.720	<.001	.003	3	2
UCEC	c-Kit →	-0.182	-2.000	.046	.010	3	2
UCEC	14-3-3_beta →	-0.100	-3.432	.010	.005	3	1
UCEC	eEF2 →	+0.412	+3.321	.003	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

PEA-15_pS116 by KCNJ1 expression — UCEC

Explore this box plot interactively →