KCNJ1

Across TCGA cell cohorts, KCNJ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,802 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KCNJ1-associated GO terms across cancer lineages are Regulation of cell cycle G1/S phase transition, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Regulation of G1/S transition of mitotic cell cycle. Each is linked with KCNJ1 in more than 6 cancer types. Because this analysis shows association rather than direction, both KCNJ1-to-partner and partner-to-KCNJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle G1/S phase transition grouped by KCNJ1-low versus KCNJ1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNJ1→partner) and Y-score (partner→KCNJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of cell cycle G1/S phase transition →	+0.047	+0.058	<.001	.009	3	7
BREAST	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.080	+0.079	.007	.002	3	6
BLOOD_Lymphoma	Regulation of G1/S transition of mitotic cell cycle →	+0.052	+0.218	<.001	.001	3	6
SOFT_TISSUE	Positive regulation of DNA-templated transcription, elongation →	+0.059	+0.080	<.001	.002	3	5
SOFT_TISSUE	Positive regulation of transcription elongation by RNA polymerase II →	+0.074	+0.095	<.001	.006	3	5
OVARY	Regulatory ncRNA-mediated gene silencing →	+0.058	+0.272	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,802 associations by consensus.

Regulation of cell cycle G1/S phase transition by KCNJ1 expression — SOFT_TISSUE

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