KCNH6

Across TCGA pan-cancer cohorts, KCNH6 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KCNH6 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher KCNH6 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated KCNH6 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

LUSC, LGG, and BLCA are the cancer types where KCNH6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	1.000	0.751	.013	9	view →
LGG	OS	Median	All	0.324	0.811	.012	6	view →
BLCA	OS	Median	All	0.156	0.593	.011	6	view →
SKCM	DFS	Median	IV	1.000	0.201	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KCNH6–LUSC (OS)

Open the LUSC breakdown →