KCNH6

Across TCGA patient cohorts, KCNH6 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,069 significant associations in total. LGG shows the largest number of these associations.

The most reproducible KCNH6-associated GO terms across cancer lineages are Neurotransmitter secretion, Obsolete histone modification, and Cytoskeleton-dependent intracellular transport. Each is linked with KCNH6 in more than 17 cancer types. Because this analysis shows association rather than direction, both KCNH6-to-partner and partner-to-KCNH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neurotransmitter secretion grouped by KCNH6-low versus KCNH6-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH6→partner) and Y-score (partner→KCNH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Neurotransmitter secretion →	+0.120	+1.880	<.001	<.001	3	18
STAD	Obsolete histone modification →	+0.053	+0.294	<.001	<.001	3	18
SCLC	Cytoskeleton-dependent intracellular transport →	+0.077	+1.605	<.001	<.001	3	18
SCLC	Regulation of microtubule polymerization →	+0.117	+1.700	<.001	<.001	3	18
SCLC	Regulation of autophagy of mitochondrion →	+0.101	+1.753	<.001	<.001	2	18
STAD	Positive regulation of double-strand break repair →	+0.052	+0.331	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,069 associations by consensus.

Neurotransmitter secretion by KCNH6 expression — SCLC

Explore this box plot interactively →